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Academics

Dr Rhys Evans

Fellow by Special Election

Reader in the Department of Physiology, Anatomy and Genetics

Welcome

A warm welcome from Medicine and Physiology at Keble College. If you are interested in these subjects, Keble College is able to provide a comprehensive package of teaching and support from an enthusiastic and dedicated set of tutors with backgrounds in a wide variety of relevant subjects, including my own, metabolic biochemistry. This key subject straddles biochemistry and physiology, and has great relevance to a variety of common medical disorders. The metabolic diseases are now recognised as one of the major contributors to morbidity and mortality and hence they are attracting considerable research interest. It is therefore a core topic in several university undergraduate courses, including medicine. We aim to provide comprehensive teaching of metabolism and emphasise relevance and applicability to common medical disorders.

Research Interests

  • regulation of lipid and lipoprotein metabolism
  • structure and function of very-low-density lipoprotein (VLDL)
  • substrate utilisation and selection in health and disease

Recent Publications

  • Evans R. and Clarke, K., 'Myocardial substrate metabolism in heart disease' in Frontiers in Bioscience, 4 (2012), 556-80
  • Johnson, A.W. et al., 'Energetic and functional abnormalities in human heart failure ...' in Circulation (2012)
  • Y-G. Niu & R.D. Evans, 'Very-Low-Density Lipoprotein: Complex Particles in Cardiac Energy Metabolism' in Journal of Lipids , 2011 (2011), 189876
  • L.C. Heather, M.A. Cole, H.J. Atherton, W.A. Coumans, R.D. Evans, D.J. Tyler, J.F.C. Glatz, J.J.F.P. Luiken & K. Clarke, 'Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart' in Endocrinology , 24 (2010), 422-431
  • Y. Niu & R.D. Evans, 'Myocardial metabolism of triacylglycerol-rich lipoproteins in type 2 diabetes' in Journal of Physiology , 587 (2009), 3301-3315
  • Y. Niu & R.D. Evans, 'Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference' in American Journal of Physiology , 295 (2008), E1106-E1116
  • L.C. Heather, M.A. Cole, C.A. Lygate, R.D. Evans, D.J. Stuckey, A.J. Murray, S. Neubauer & K. Clarke, 'Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart' in Cardiovascular Research, doi:10.1016/j.cardiores.2006.08.020 (2006)
  • Y. Niu, D. Hauton & R.D. Evans, 'Utilisation of diabetic VLDL by isolated working rat heart' in Proceedings of the International Society for Heart Research, 25 (2005), 69-73
  • 'Cardiothoracic emergencies' in Emergencies in Anaesthesia, ed. Allman, K., McIndoe, A. & Wilson, I (Oxford University Press, 2005)
  • 'Cardiac' in Oxford Handbook of Anaesthesia, ed. Allman, K. & Wilson, I. (Oxford University Press, 2005)
  • Y-G. Niu, D. Hauton & R.D. Evans, 'Utilisation of diabetic VLDL by isolated working rat heart' in Journal of Molecular and Cellular Cardiology, 38 (2005), 1019-1020
  • C.R. Grebenik, A.Boyce, M.E. Sinclair, R.D. Evans & B. Martin, 'NICE guidelines for central venous catheterization in children. Is the evidence base sufficient?' in British Journal of Anaesthesia, 92 (2004), 827-830
  • Y-G Niu, D. Hauton & R.D. Evans, 'Utilisation of triacylglycerol-rich lipoproteins by the working rat heart:' in Journal of Physiology, 558 (2004), 225-237
  • X. Wang & R.D. Evans, 'Comparison of the effect of propofol and fentanyl on myocardial LPL and fatty acid metabolism in isolated perfused and reperfused working rat heart' in Anesthesiology, 99 (2003), A63
  • 'Fatty acid and triacylglycerol utilisation by perfused rat spleen: differential metabolic fate and the effect of endotoxin' in Cellular Physiology and Biochemistry, 12 (2002), 143-152
  • 'Utilisation of fatty acid and triacylglycerol by rat macrophages: the effect of endotoxin' in Cellular Physiology and Biochemistry, 12 (2002), 293-304
  • 'Utilisation of triacylglycerol and non-esterified fatty acid by the working rat heart: myocardial lipid substrate preference' in Biochimica et Biophysica Acta [Molecular and Cell Biology of Lipids], 1533 (2001), 99-109
  • 'Perfused heart studies to investigate lipid metabolism' in Biochemical Society Transactions, 28 (2000), 113-120
  • 'Preparation of radiolabelled very-low-density lipoprotein (VLDL) in high yield by extended rat liver perfusion' in Biotechnology Letters, 22 (2000), 301-306
  • 'Prior exercise and postprandial substrate extraction across the human leg' in American Journal of Physiology [Endocrinology & Metabolism], 279 (2000), 1020-1028
  • 'Utilization of very low density lipoprotein by rat heart: the effect of endotoxin' in American Journal of Physiology [Endocrinology and Metabolism], 278 (2000), 802-810

Academic Biography

  • Reader in the Nuffield Department of Anaesthetics (2002 - present)
  • Fellow by Special Election Keble College Oxford (1999 - present)
  • Consultant Paediatric Cardiothoracic Anaesthetist Radcliffe Hospitals NHS Trust Oxford (1993 - present)
  • Senior Clinical Lecturer Nuffield Department of Anaesthetics University of Oxford (1993 - 2002)
  • EPA Junior Research Fellow Keble College Oxford (1990 - 1993)
  • Clinical Lecturer Nuffield Department of Anaesthetics University of Oxford (1986 - 1990)

College Contact Details

Dr Rhys Evans
Keble College
Oxford
OX1 3PG
UK
Telephone: 01865 272445
Fax: 01865 282272
Email:

Faculty/Dept. Information

Department of Physiology, Anatomy and Genetics
Sherrington Building
South Parks Road
Oxford OX1 3PT

Website:
http://www.dpag.ox.ac.uk/