You are here: Home Teaching & Research Academic staff by name Professor Jonathan Hodgkin FRS


Professor Jonathan Hodgkin FRS

Professor of Genetics

Emeritus Fellow


I was a Professorial Fellow of the College and holder of the Genetics Chair in the Department of Biochemistry; I am now an Emeritus Fellow.  Research in my laboratory is devoted to investigations of genetics, development and immunity.   We work with a tiny nematode worm called C. elegans, which is a popular “model organism” for analysing many fundamental problems in biology and medicine.

Research Interests

  • Developmental and molecular genetics of the nematode Caenorhabditis elegans, with particular reference to nematode-bacterial interactions, innnate immunity and pathogenesis.
  • Developmental morphogenesis
  • Sex determination
  • Hypoxia
  • Informational suppression and gene interaction
  • Germline immortality and telomere function
  • Behavioural genetics and neurogenetics
  • Natural variation
  • Genomics
  • Gene mapping
  • Genetic nomenclature

Recent Publications

  • Hodgkin, J., Felix, M.A., Clark, L.C., Stroud, D., and Gravato-Nobre, M.J., 'Two Leucobacter strains exert complementary virulence on Caenorhabditis including death by worm-star formation' in Current Biology, 23(21) (2013), 2157-61
  • Burlinson, P. ... Hodgkin, J. et al., 'Pseudomonas fluorescens NZ17 repels grazing by C. elegans, a natural predator' in ISME J., 7(6) (2013), 1126-38
  • O’Rourke D, Baban D, Demidova M, Mott R, Hodgkin J, 'Genomic clusters, putative pathogen recognition molecules and antimicrobial genes are induced by infection of C. elegans with M. nematophilum' in Genome Research, 16 (2006), 1005-1016
  • Novelli J, Page AP, Hodgkin J, 'The C-terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.' in Genetics, 172 (2006), 2253-2267
  • Gravato-Nobre MJ, Nicholas HR, Nijland R, O'Rourke D, Whittington DE, Yook KJ, Hodgkin J, 'Multiple genes affect sensitivity of C. elegans to the bacterial pathogen M. nematophilum.' in Genetics, 171 (2005), 1033-1045
  • Bishop T, Lau KW, Epstein AC, Kim SK, Jiang M, O'Rourke D, Pugh CW, Gleadle JM, Taylor MS, Hodgkin J, Ratcliffe PJ, 'Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.' in PLoS Biology, 2 (2004), e289
  • Nicholas HR, Hodgkin J, 'The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.' in Current Biology, 14 (2004), 1256

Academic Biography

  • Professor of Genetics and Head of Genetics Unit, University of Oxford; Fellow of Keble College, Oxford (2000 - present)
  • Curator, C. elegans Genetic Map and Nomenclature (1992 - present)
  • Visiting professor, Dept. of Biochemistry, University of Wisconsin, Madison, WI (1989 - 1990)
  • Non-clinical scientific staff member, MRC Laboratory of Molecular Biology (1977 - 1999)
  • Postdoctoral, Dept. of Biochemistry, Stanford, CA. (Adviser: Professor Dale Kaiser; studying gliding motility and genetics of myxobacteria) (1974 - 1976)
  • Darwin College, University of Cambridge Ph.D. Biology (1971 - 1974)
  • Graduate student, MRC-LMB, Cambridge (Supervisor: Dr. Sydney Brenner; studying neurogenetics and development in the nematode C. elegans) (1971 - 1974)
  • Merton College, University of Oxford BA Zoology (1967 - 1971)

College Contact Details

Professor Jonathan Hodgkin FRS
Keble College
Telephone: 01865 275317
Fax: 01865 275318

Faculty/Dept. Information

Genetics Unit
Department of Biochemistry
University of Oxford